No, no issues so far, as me I am using the system for mundane tasks, but knowing that the AMD's interpretation of the smt is for the 2 threads to use the same FPU I prefer to have that FPU fully available on a single thread in case I decide I need it, most probably for some video transcoding.
I don't think you can program the HDD not to spin down, I think most modern HDDs DO spin down, except maybe the enterprise models built for 24/7 duty. I have an external Ironwolf 4TB and I hear it spinning up every time I am looking for something on it.
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