I had one using P45 chipset and Q6600. However, I was using the spec Gigabyte board that they recommended. It worked pretty well until I upgraded to Ivy Bridge built which is a bit buggy in terms of audio and USB 3.0.
Snow Leopard works really well on just a C2D E8400 and 4 GB of RAM. A Geforce 8400GS or Radeon HD 5450 should give you the acceleration you need for QE/CI and some apps. VLC doesn't work without OpenGL acceleration, and QE requires OpenCL.
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