The GPU doesn't interfere with the AIO least didn't in my build. The the build inside here it blasted out the side 

Hmm? Even cards with triple fans on them, they are still pushing air into the heatsink, they aren't pulling it out. The air should be forced out the vent by the IO ports. I'm sure some "leaks" as that vent is obviously not an adequate size, but it would still rise as heat naturally does. I don't see how it would be dumping heat towards the glass/side panel.And unless you have a blower or water cooling for your gpu, it's dumping heat towards the glass, away from airflow.
Hmm? Even cards with triple fans on them, they are still pushing air into the heatsink, they aren't pulling it out. The air should be forced out the vent by the IO ports. I'm sure some "leaks" as that vent is obviously not an adequate size, but it would still rise as heat naturally does. I don't see how it would be dumping heat towards the glass/side panel.