apparently ISA lives within the TPM system so someone made a bridge adapter that lets you use an ISA device on modern hardware.
Andy "Rasteri" Tait Brings ISA Back with a Bang — By Abusing the TPM Slot on Modern Motherboards
Designed to connect to a modern motherboard where the Trusted Platform Module will go, the dISAppointment resurrects your old ISA cards.
www.hackster.io